The retinoic acid binding protein CRABP2 is increased in murine models of degenerative joint disease |
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| Authors: | Ian D Welch Matthew F Cowan Frank Beier and Tully M Underhill |
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| Institution: | (1) Department of Animal Care and Veterinary Services, University of Western Ontario, London, Ontario, N6A 5C1, Canada;(2) Department of Cellular and Physiological Sciences, The University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada;(3) Department of Physiology and Pharmacology, CIHR Group in Skeletal Development and Remodeling, The University of Western Ontario, London, Ontario, N6A 5C1, Canada |
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| Abstract: | Introduction Osteoarthritis (OA) is a debilitating disease with poorly defined aetiology. Multiple signals are involved in directing the
formation of cartilage during development and the vitamin A derivatives, the retinoids, figure prominently in embryonic cartilage
formation. In the present study, we examined the expression of a retinoid-regulated gene in murine models of OA. |
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