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Flow cytometry analysis of glucocorticoid receptor expression and binding in steroid-sensitive and steroid-resistant patients with systemic lupus erythematosus
Authors:Juan Du   Min Li   Denghai Zhang   Xiaoyan Zhu   Weiwei Zhang   Wei Gu   Yinglu Feng   Xiaofeng Zhai  Changquan Ling
Affiliation:(1) Department of Integrative Medicine, Changhai Hospital, The Second Military Medicine University, No.168 Changhai Road, Shanghai, PR China;(2) Department of Naval Medicine, The Second Military Medicine University, No.800 Xiangyin Road, Shanghai, PR China;(3) Department of physiology, The Second Military Medicine University, No.800 Xiangyin Road, Shanghai, PR China;(4) Department of Medical Technology, Changhai Hospital, The Second Military Medicine University, No.168 Changhai Road, Shanghai, PR China
Abstract:

Introduction  

Glucocorticoid (GC) therapy is the main treatment for systemic lupus erythematosus (SLE). However, some patients are resistant to these agents. Abnormalities of glucocorticoid receptor (GR) seem to be related to steroid resistance. This study evaluated GRs in T lymphocytes and monocytes of SLE patients by flow cytometry (FCM) using a monoclonal antibody (mAb) and FITC-Dex probes.
Keywords:
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