|
|||||
|
|
Synthesis and anti-hepatitis C virus activity of nucleoside derivatives of N3, 5'-anhydro-4-(beta-D-ribofuranosyl)-8-aza-purin-2-ones |
|
| Authors: | Hassan Abdalla E A Wang Peiyuan McBrayer Tamara R Tharnish Phillip M Stuyver Lieven J Schinazi Raymond F Otto Michael J Watanabe Kyoichi A |
| Affiliation: | Department of Chemical Sciences, Pharmasset, Inc., Tucker, Georgia, USA. |
| Abstract: | A series of N3, 5-Anhydro-4-(beta-D-ribofuranosyl)-8-azapurin-2-ones were prepared in multistep reactions from uridine as potential anti-hepatitis C virus (HCV) agents. The synthetic details as well as biological evaluations are discussed. |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ | |