pH excursions impact CHO cell culture performance and antibody N-linked glycosylation |
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| Authors: | Jiang Rubin Chen Hao Xu Sen |
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| Affiliation: | 1.Biologics Process Research and Development, Process Research and Development, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, 07033, USA
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| Abstract: | Bioprocess and Biosystems Engineering - pH excursions exist due to frequent base addition and environmental heterogeneity in large-scale bioreactors. Such excursions could lead to suboptimal... |
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