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The Metabolic Map into the Pathomechanism and Treatment of PGM1-CDG
Affiliation:1. Metabolomics Expertise Center, Center for Cancer Biology, VIB Center for Cancer Biology, 3000 Leuven, Belgium;2. Laboratory of Hepatology, Department of Chronic Diseases, Metabolism and Aging, Katholieke Universiteit Leuven, 3000 Leuven, Belgium;3. Metabolomics Expertise Center, Department of Oncology, Katholieke Universiteit Leuven, 3000 Leuven, Belgium;4. Clinical Department of Laboratory Medicine, University Hospitals Leuven, 3000 Leuven, Belgium;5. Department of Anatomy, Radboud University Medical Centre, Donders Institute for Brain Cognition and Behaviour, 6535 HR Nijmegen, the Netherlands;6. Hayward Genetics Center, Tulane University School of Medicine, New Orleans, LA 70112, LA, USA;7. Biochemistry Department, University of Missouri, Columbia, MO 65211, USA;8. Center for Child and Adolescent Medicine, Department I, University of Heidelberg, 69120 Heidelberg, Germany;9. Centre for Organismal Studies, University of Heidelberg, 69120 Heidelberg, Germany;10. Center of Individualized Medicine, Department of Clinical Genomics, Mayo Clinic, Rochester, MN 55905, USA;11. Metabolic Center, University Hospitals Leuven, 3000 Leuven, Belgium;12. Medical Genetics Department, Montréal Children’s Hospital, McGill University, Montreal, QC H4A3J1, Canada;13. Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, 12108 Prague, Czech Republic;14. Department of Pediatric Metabolism and Nutrition, Ankara University School of Medicine, 06560 Ankara, Turkey;15. Phoenix Children’s Medical Group, Genetics and Metabolism, Phoenix Children’s Hospital, Phoenix, AZ 85016, USA;16. Division of Human Genetics, Department of Pediatrics, the Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA;17. Department of Pediatrics, United Arab Emirates University, Al Ain, United Arab Emirates;18. Department of Cardiovascular Sciences, Katholieke Universiteit Leuven, 3000 Leuven, Belgium
Abstract:
Keywords:glycosylation  galactose  PGM1-CDG  CDG  tracer metabolomics  nucleotide sugars  central carbon metabolism  mitochondria
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