Role of Wnt signaling in fracture healing |
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| Authors: | Huiyun Xu Jing Duan Dandan Ning Jingbao Li Ruofei Liu Ruixin Yang Jean X. Jiang Peng Shang |
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| Affiliation: | 1.Key Laboratory for Space Biosciences & Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, Shaanxi Province 710072, People’s Republic of China;2.Department of Biochemistry, University of Texas Health Science Center at San Antonio, Texas 78229, the United States |
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| Abstract: | The Wnt signaling pathway is well known to play major roles in skeletal development and homeostasis. In certain aspects, fracture repair mimics the process of bone embryonic development. Thus, the importance of Wnt signaling in fracture healing has become more apparent in recent years. Here, we summarize recent research progress in the area, which may be conducive to the development of Wnt-based therapeutic strategies for bone repair. [BMB Reports 2014; 47(12): 666-672] |
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| Keywords: | Wnt signaling pathway, Fracture healing, β -catenin, Sost, GSK-3β |
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