Radiation-induced human chromosome aberrations. II. Human in vitro irradiation compared to in vitro and in vivo irradiation of marmoset leukocytes |
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Authors: | J G Brewen N Gengozian |
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Affiliation: | 1. Biology Division, Oak Ridge National Laboratory∗∗, USA;2. Medical Division, Oak Ridge Associated Universities∗∗∗ Oak Ridge, Tenn., U.S.A. |
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Abstract: | Whole blood cultures from humans and from the New World primate, Saguinus fuscicollis, were irradiated with various doses of 250 kV X-rays. The resulting centric ring plus dicentric aberration yields were fitted to the three models, Y = a+bD, Y = a+bD+cD2, and Y = a+cD2, by least squares regression. In both instances the best fit was to the model Y = a+bD+cD2, with coefficients of the one- and two-track components for human and marmoset being: b = (0.78 ± 0.09)·10−3, c = (5.92 ± 0.31)·10−6, and b = (1.11 ± 0.36)·−3, c = (7.7 ± 1.7)·10−6, respectively. |
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Keywords: | LET, linear energy transfer RBE, relative biological effectiveness |
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