生长激素/胰岛素样生长因子1与阿尔茨海默病

生长激素／胰岛素样生长因子-1（GH／IGF-1）轴的合成、分泌、调节及生物学活性与阿尔茨海默病（AD）有密切关系。生长激素（GH）的合成和分泌受生长激素释放激素（GHRH）正向调节。GH／IGF-1轴活性下降导致一系列生理功能变化。GH／IGF-1缺乏可引起衰老及神经退行性变（AD）而导致认知功能的下降，相应激素的补给可以抑制或逆转这种认知障碍。越来越多的证据表明：GH／IGF-1参与AD型痴呆病理过程，对AD有很好的治疗应用前景。本文就生长激素／胰岛素样生长因子1在AD发病中的机理和药理学研究做一综述。

Growth hormone/insulin-like growth factor 1 and Alzheimer's disease

The synthesis,secretion,regulation and biological activity of the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) play important parts in the development of Alzheimer's disease (AD).The synthesis and secretion are regulated by the stimulants,the GH-releasing hormone (GHRH).Decrement of the activity of the somatotrophic axis causes a series of changes of physiological functions.The deficiency of GH/IGF-1 results in aging and decline of cognition.Supplementation of the related hormones will protect or reverse the cognitive deficits.The evidence available strongly indicates that GH/IGF-1 therapy in Alzheimer's dementia may be addressing pathogenic processes.The role of GH/IGF-1 in the development of Alzheimer's disease and pharma- cological research are reviewed