Some studies of erythroid differentiationin vitro

Summary When rat marrow cells are pre-incubated for periods of up to 20 days they retain the capacity to respond to exogenous erythropoietin. This is true whether the response is measured in terms of increased rates of RNA synthesis, protein synthesis, iron-uptake, or hemoglobin synthesis. The patterns of response to erythropoietin by pre-incubated cells are complex and involve secondary waves of increased rates of synthesis that are not yet understood. Life Insurance Medical Research Fund Fellow. Operated by the University of Chicago for the United States Atomic Energy Commission.