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A highly efficient construction of GM1 epitope tetrasaccharide and its conjugation with KLH |
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| Authors: | Takeru Yoshikawa Yuki Kato Nobuhiro Yuki Tomio Yabe Hideharu Ishida Makoto Kiso |
| Institution: | Department of Applied Bio-organic Chemistry, Gifu University, Gifu 501-1193, Japan. |
| Abstract: | GM1 epitope tetrasaccharide was synthesized by a condensation of sialyl-alpha(2-3)-gal acceptor and gal-beta(1-3)-GalN donor in a highly efficient manner. After introduction of mercaptohexanol to the tetrasaccharide, it was coupled to maleimide-activated KLH carrier protein to give the desired GM1 epitope-KLH conjugate. |
| Keywords: | Lipo-oligosaccharide GM1 Guillain– Barré syndrome Keyhole limpet hemocyanin |
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