|
|||||
|
|
| 大肠癌组织及癌旁组织中c-myc,COX-2和CD44v6基因表达量差异的检测 | |
| 引用本文： | 邓黎莉,乞宗泰,黄欢,赵建华,周国华.大肠癌组织及癌旁组织中c-myc,COX-2和CD44v6基因表达量差异的检测[J].现代生物医学进展,2010,10(5). |
| 作者姓名： | 邓黎莉 乞宗泰 黄欢 赵建华 周国华 |
| 作者单位： | 1. 中国药科大学生命科学与技术学院,江苏南京,210009 2. 华东生物医学研究所,江苏南京,210002 3. 江苏省肿瘤医院,江苏南京,210000 4. 中国药科大学生命科学与技术学院,江苏南京,210009;华东生物医学研究所,江苏南京,210002 |
| 基金项目： | 南京市科技发展计划项目指令性计划(200801087) |
| 摘 要： | 目的:通过检测大肠癌组织和癌旁组织中c-myc,COX-2以及CD44v6的表达水平,探讨这三种基因在大肠癌发生和发展中的意义。方法:应用实时荧光定量PCR技术检测了10例大肠癌组织和相应癌旁组织中c-myc,COX-2以及CD44v6基因表达水平的差异,并探讨了各基因在癌组织中的表达水平与大肠癌临床病理指标之间的关系。结果:c-myc,COX-2以及CD44v6在大肠癌组织和癌旁组织中的表达均有非常显著性差异(P<0.01);癌组织中COX-2和CD44v6的表达与淋巴结转移、分化程度及Dukes分期有关(P<0.05)。结论:c-myc,COX-2和CD44v6的异常表达均与大肠癌密切相关,三者从不同方面对大肠癌的发生和发展起到了重要作用,可作为早期诊断和预后的参考指标。 |
| 关 键 词： | c-myc COX-2 CD44v6 大肠癌 实时荧光定量PCR |
Differential expression detection of c-myc,COX-2 and CD44v6 genes in colorectal cancer tissues and adjacent corresponding nonmalignant tissues |
|
| DENG Li-li,QI Zong-tai,HUNG Huan,ZHAO Jian-hua,ZHOU Guo-hua.Differential expression detection of c-myc,COX-2 and CD44v6 genes in colorectal cancer tissues and adjacent corresponding nonmalignant tissues[J].Progress in Modern Biomedicine,2010,10(5). | |
| Authors: | DENG Li-li QI Zong-tai HUNG Huan ZHAO Jian-hua ZHOU Guo-hua |
| Institution: | DENG Li-li1,QI Zong-tai1,HUNG Huan2,ZHAO Jian-hua3,ZHOU Guo-hua1,2 (1 College of Life Science , Technology,China Pharmaceutical University,Nanjing 210009,China,2 Huadong Research Institute for Medicine , Biotechnics,Nanjing 210002,3 Jiangsu Cancer Hospital,Nanjing 210000,China) |
| Abstract: | Objective:To compare the expression of c-myc,COX-2 and CD44v6 in colorectal cancer tissues and adjacent corresponding nonmalignant tissues and to evaluate their significance in the occurrence and development of colorectal cancer.Methods : Real-time PCR was used to quantify the expression of c-myc,COX-2 and CD44v6 in colorectal cancer tissues and adjacent corresponding nonmalignant tissues from ten patients.The relationships between the expression level of each gene and the pathologic parameters were also in... |
| Keywords: | C-myc COX-2 CD44v6 Colorectal Cancer Real-time PCR |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |