Inhibitory effects of carcinogenic mycotoxins on deoxyribonucleic acid-dependent ribonucleic acid polymerase and ribonuclease H.

Fourteen mycotoxins were tested for inhibitory effects on ribonucleic acid polymerase of rat liver and Escherichia coli and nuclear ribonuclease H of rat liver and Tetrahymena pyriformis. These enzymes were strongly inhibited by (-)-luteoskyrin, (+)-rugulosin, patulin, and PR toxin.