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Comparison of expression of the fragile site at Xq27 in T and B lymphocytes |
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| Authors: | Cristiana A Marchese Ming S Lin Miriam G Wilson |
| Institution: | (1) Genetics Division, University of Southern California School of Medicine, Los Angeles, USA;(2) Los Angeles County-University of Southern California Medical Center, Los Angeles, USA;(3) Present address: Istituto di Genetica Medica, Università di Torino, Via Santena 19, I-10126 Torino, Italia |
| Abstract: | Summary We compared the fragile X (fraX) expression in T and B lymphocytes from four hemizygous males with fraX. Blood cultures were stimulated with a T cell mitogen (phytohemagglutinin: PHA) and with a B cell mitogen (pokeweed mitogen: PWM). A significant decrease in fraX expression was observed in cultures stimulated with PWM when compared to PHA-stimulated ones. |
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