Synthesis of N6-substituted 9-[3-(phosphonomethoxy)propyl]adenine derivatives as possible antiviral agents |
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Authors: | El-Kattan Yahya Lin Tsu-Hsing Wu Minwan Kumar V Satish Kotian Pravin L Ghosh Ajit Cheng Xiaogang Bantia Shanta Babu Yarlagadda S Chand Pooran |
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Affiliation: | BioCryst Pharmaceuticals, Inc., 2190 Parkway Lake Drive, Birmingham, AL 35244, USA. |
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Abstract: | A number of N6-substituted 9-[3-(phosphonomethoxy)propyl]adenine derivatives having hydroxymethyl at C-1' position were prepared from the appropriate 6-chloroadenine derivative. The syntheses of the corresponding prodrugs of these compounds are also reported. These compounds showed poor activity against HCV in replicon assay. |
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