Lactogenesis induced by ovariectomy in pregnant rats and its regulation by oestrogen and progesterone |
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| Authors: | R P Deis C Delouis |
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| Institution: | 1. Laboratoire de Physiologie de la Lactation, INRA-CNRZ, 78350 Jouy-en-Josas, France;1. Laboratorio de Reproduccion y Lactancia-Larlac-Conicet, Casilla de Correo 855, Mendoza 5500, Argentina;1. College of Information Engineering, Nanjing University of Finance and Economics, Nanjing, Jiangsu 210023, PR China;2. School of Automation, Southeast University, Nanjing, Jiangsu 210096, PR China;3. Research Institute of Intelligent Control and Systems, Harbin Institute of Technology, Harbin, Heilongjiang 150001, PR China |
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| Abstract: | Ovariectomy on day 19 of pregnancy augmented galactosyl transferase activity 24 h after surgery preceding by 6 h the significant alpha-lactalbumin accumulation. Progesterone, injected immediately after ovariectomy showed a clear inhibitory effect on both galactosyl transferase and alpha-lactalbumin concentration, measured 30 h after ovariectomy. However, once the synthesis of lactose has been induced, progesterone is no longer inhibitory. Oestrogen induced a significant increase in lactose synthetase activity but no effect was obtained on galactosyl transferase activity. Progesterone, in a time and dose dependent relationship, was capable of preventing the effect of estrogen on lactogenesis. The lactogenic action of oestrogen in ovariectomized pregnant rats might be due to a direct effect at the mammary gland level facilitating the action of prolactin or through an indirect effect mediated via an increase on prolactin release. |
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