Assisting effects of lithium on hypoglycemic treatment in patients with diabetes |
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Authors: | Min Hu Hanwen Wu Chusheng Chao |
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Institution: | (1) The Institute of Metabolism and Endocrinology, The Second Affiliated Hospital Hunana Medical University, 410011 Changsha, Hunan, PROC |
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Abstract: | In this article, we report the assisting effect of lithium on hypoglycemic treatment in patients with diabetes. Thirty-eight
diabetic patients, 15 male and 23 female, aged 20–70 yr, 33 noninsulin-dependent diabetesmellitus (NIDDM) patients, and 5 insulin-dependent diabetesmellitus (IDDM) patients, were recruited in this study. Fasting and 1-h postprandial blood glucose (BG) profiles were undertaken from
three groups of patients with diabetes before and after short-term of treatment of lithium carbonate. Group I was treated
with diet only, Group II with oral hypoglycemic agents (OHA), and Group III with insulin.
The fasting blood glucose (FBG) level and 1-h postprandial blood glucose (1-h PBG) level before and after treatment of lithium
were: Group I: FBG: 7.67 ± 0.48 vs 7.13 ± 0.82; 1-h PBG 15.13 ± 0.88 vs 10.33 ± 0.96; Group II: FBG: 8.84 ± 0.67 vs 6.04 ±
0.57; 1-h PBG: 12.33 ± 0.72 vs 9.95 ± 0.82; Group III: FBG: 10.87 ± 0.83 vs 6.83 ± 0.79; 1-h PBG: 12.45 ± 0.93 vs 9.17 ± 1.00
mmol/L, respectively. The FBG and PBG of all three groups decreased significantly after lithium treatment, except the FBG
in Group I. These data suggest that combined with other therapy, lithium could improve glucose metabolism in most patients
with diabetes. Our results suggest that lithium has an assisting hypoglycemic effect on antidiabetic treatment. |
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Keywords: | Lithium diabetes blood glucose |
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