Failure of thymidine kinase-negative herpes simplex virus to reactivate from latency following efficient establishment |
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| Authors: | Chen Shih-Heng Pearson Angela Coen Donald M Chen Shun-Hua |
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| Institution: | Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan 70101, Republic of China. |
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| Abstract: | Thymidine kinase-negative mutants of herpes simplex virus did not reactivate from latency in mouse trigeminal ganglia, even when their latent viral loads were comparable to those that permitted reactivation by wild-type virus. Thus, reduced establishment of latency does not suffice to account for the failure to reactivate. |
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