Effects of administration of Embelin and Curcumin on lipid peroxidation, hepatic glutathione antioxidant defense and hematopoietic system during N-nitrosodiethylamine/Phenobarbital-induced hepatocarcinogenesis in Wistar rats |
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Authors: | Meenakshisundaram Sreepriya Geetha Bali |
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Institution: | (1) Department of Microbiology and Biotechnology, Bangalore University, Jnana Bharati Campus, Bangalore, 560 056, Karnataka, India |
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Abstract: | The effects of administration of Embelin (EMB) and Curcumin (CUR) on lipid peroxidation, hepatic glutathione antioxidant defense
and hematopoietic cells were examined during N-nitrosodiethylamine (DENA-200 mg kg−1body wt, single I.P injection) initiated and Phenobarbital (PB-0.05% in drinking water orally for 13 weeks) promoted hepatocarcinogenesis
in Wistar strain male albino rats. DENA/PB-induced hepatic damage was manifested by a significant drop in the hepatic glutathione
antioxidant defense, increased lipid peroxidation and histological alterations like dysplasia, and atypical cells with abnormal
chromatin pattern. Treatment with Curcumin (100 mg kg−1body wt) and Embelin (50 mg kg−1body wt) prevented the drop in hepatic glutathione antioxidant defense, decreased lipid peroxidation, minimized the histological
alterations induced by DENA/PB, but showed toxic effects on the hematopoietic cells. Results indicate the beneficial effects
of Embelin and Curcumin against oxidative tissue damage during chemically-induced hepatocarinogenesis in rats. |
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Keywords: | DENA Phenobarbital hepatocarcinogenesis antioxidants hematopoietic cells |
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