Frequency distribution of XbaIG > T and HaeIIIT > C <Emphasis Type="Italic">GLUT1</Emphasis> polymorphisms among different Brazilian ethnic groups |
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Authors: | G C S Costa L C J Alcantara R Azevedo G Muricy S H Kashima D T Covas B Galvão-Castro S R Gadelha |
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Institution: | 1.Laboratório Avan?ado de Saúde Pública, Centro de Pesquisas Gon?alo Moniz, Funda??o Oswaldo Cruz,Salvador,Brazil;2.Escola Bahiana de Medicina e Saúde Pública,Salvador,Brazil;3.Laboratório de Biologia Molecular, Banco de Sangue Regional de Ribeir?o Preto, Faculdade de Medicina de Ribeir?o Preto,Universidade de S?o Paulo,S?o Paulo,Brazil;4.Universidade Estadual de Santa Cruz,Ilheús,Brazil |
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Abstract: | GLUT is the major glucose transporter in mammalian cells. Single nucleotide polymorphisms (SNP) at GLUT1 promoter and regulatory regions have been associated to the risk of developing nephropathy in different type 1 and type 2
diabetic populations. It has been demonstrated that differences in allelic and genotypic frequencies of GLUT1 gene (SLC2A1) polymorphisms occur among different populations. Therefore, ethnic differences in distribution of GLUT1 gene polymorphisms may be an important factor in determining gene-disease association. In this study, we investigated the
XbaIG > T and HaeIIIT > C polymorphisms in six different Brazilian populations: 102 individuals from Salvador population (Northern
Brazil), 56 European descendants from Joinville (South Brazil), 85 Indians from Tiryió tribe (North Brazil) and 127 samples
from Southern Brazil: 44 from European descendants, 42 from African descendants and 41 from Japanese descendants. Genotype
frequencies from both sites did not differ significantly from those expected under the Hardy–Weinberg equilibrium. We verified
that the allele frequencies of both polymorphisms were heterogeneous in these six Brazilian ethnic groups. |
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