Cytotoxic prodigiosin family pigments from Pseudoalteromonas sp. 1020R isolated from the Pacific coast of Japan |
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| Authors: | Yi Wang Aya Nakajima Kakushi Hosokawa Azamjon B Soliev Issey Osaka Ryuichi Arakawa Keiichi Enomoto |
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| Affiliation: | Department of Environmental Systems Engineering, Kochi University of Technology, Kochi, Japan. |
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| Abstract: | Pseudoalteromonas sp. 1020R, isolated from the Pacific coast of Japan, produces prodigiosin family pigments. Structural analysis indicated that these are prodigiosin (2-methyl-3-pentyl-prodiginine) and three other prodigiosin congeners which differ only in the lengths of the alkyl side chains. These compounds exhibited different extents of cytotoxicity against U937 leukemia cells, and cell death was accompanied by typical features of apoptosis. |
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