Synthesis of two carboxylic haptens for raising antibodies to 25-hydroxyvitamin D<sub>3</sub> and 1α,25-dihydroxyvitamin D<sub>3</sub>期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Synthesis of two carboxylic haptens for raising antibodies to 25-hydroxyvitamin D₃ and 1α,25-dihydroxyvitamin D₃

Authors:	Carlos Gregorio, Silvina Eduardo, Luis C. Rodrigues, Marí a A. Regueira, Ram n Fraga, Ricardo Riveiros, Miguel Maestro,Antonio Mouri o

Affiliation:	^aDepartamento de Química Orgánica y Unidad Asociada al C.S.I.C., Universidad de Santiago de Compostela, E-15706 Santiago de Compostela, Spain;^bDepartamento de Química Fundamental, Universidad de A Coruña, E-15071 A Coruña, Spain

Abstract:	Hapten derivatives of 25-hydroxyvitamin D₃ and 1α,25-dihydroxyvitamin D₃ were synthesized using the Wittig–Horner approach. Both haptens bearing a carboxylic group at the side chain that can be linked to a protein for raising antibodies of potential utility for the determination of 25-hydroxyvitamin D₃, 1α,25-dihydroxyvitamin D₃ and 1α-hydroxylated vitamin D₃ analogues.

Keywords:	25-Hydroxyvitamin D₃ 1α ,25-Dihydroxyvitamin D₃ Haptens Synthesis Wittig– Horner approach Immunoassays
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