Striatal tyrosine hydroxylases with high and low affinity for tyrosine: implications for the multiple-pool concept of catecholamines |
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| Authors: | R Kuczenski |
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| Affiliation: | Department of Psychiatry, School of Medicine University of California at San Diego La Jolla, California 92037 USA |
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| Abstract: | Synaptic membrane-bound tyrosine hydroxylase from rat striatum exhibits a decreased Km for cofactor and a decreased Km for substrate over values obtained for the soluble enzyme. The proximity of this fraction of the catecholamine biosynthetic apparatus to the probable site of neurotransmitter release and its higher affinity for substrate provide for a mechanism by which newly synthesized transmitter may be preferentially released. |
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