首页 | 本学科首页   官方微博 | 高级检索  
   检索      


A prostate-derived cDNA that is mapped to human chromosome 19 encodes a novel protein
Authors:Wang Chiang  McCarty Ida M  Balazs Louisa  Li Yi  Steiner Mitchell S
Institution:Department of Urology, University of Tennessee, 956 Court Avenue, Coleman Building, Room H202, Memphis, TN 38163, USA. cwang@utmem.edu
Abstract:The epithelial cells of prostate gland secrete various secretory products that play an important role in the growth and differentiation of prostate gland. These secretory products have also been implicated in neuroendocrine differentiation of benign prostatic hyperplasia and prostate malignancy. We have cloned a prostate-derived cDNA encoding a novel protein with a predicted molecular weight of 78 kDa (P(78)), and precisely mapped the cDNA sequence to chromosome 19. The P(78) gene has a complex genomic structure with 18 exons and 17 introns. The P(78) contains two conserved structural domains with limited similarity to domain D of synapsin I. The P(78) mRNA was expressed in various human cell lines. Western blot analysis using antibody specific for the P(78) revealed the presence of the P(78) protein in the prostate cancer cell lines with much lower level in metastatic prostate cancer cell lines compared to that in a primary prostate cancer cell line.
Keywords:Prostate cancer  Epithelium of prostate gland  Neuroendocrine cells  Neurosecretory vesicles  Neuroendocrine differentiation  A prostate-derived cDNA  Neuropeptides  Chromosome 19  Immunoprecipitation
本文献已被 ScienceDirect PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号