Receptor-Ck regulates the expression of cyclin-dependent kinase inhibitors (p16; p27)

The present study was addressed to understand the interrelationship between Receptor-C_k induction-activation coupling; isoprenoids (derived from mevalonate pathway) and cyclin-dependent kinase inhibitors. The results reported here unambiguously reveal that isoprenoids regulate the expression of genes coding for CDK inhibited p16 and p27. Further, Receptor-C_k dependent signalling, known to control the mevalonate pathway, had a direct effect upon the p27 gene expression. Based upon these studies coupled with our earlier findings we propose that Receptor-C_k has an important role in the regulation of cell cycle machinery.