Interference of gonadotropin-receptor interaction by synthetic estrogens. |
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Authors: | M R Sairam M I Berman |
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Institution: | 1. Reproduction Research Laboratory Clinical Research Institute of Montreal 110 Pine Avenue West Montreal, Quebec H2W 1R7, Canada;2. the University of Montreal Canada |
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Abstract: | In in vitro studies, the synthetic estrogens diethylstilbestrol and diethylstilbestrol sodium phosphate inhibited the binding of 125I ovine lutropin to the rat ovarian receptor and 125I ovine follitropin to the bovine testicular receptor. As the lutropin binding to receptor is affected to a greater extent, a preferential inhibitory effect may be suggested. Removal of the estrogens from the incubation medium by washing does not restore gonadotropin binding ability, indicating a strong effect. The two compounds were effective in displacing the labeled gonadotropin from the preformed receptor-hormone complex. This effect increased with time of incubation. It appears unlikely that the interference of gonadotropin-receptor interaction may be because of increased hormone and/or receptor degradation by the two compounds. |
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Keywords: | LH lutropin FSH Follitropin HCG Human Chorionic Gonadotropin E2 Estradiol 17β E2B Estradiol benzoate P Progesterone T Testosterone A Androstenedione DES Diethylstilbestrol DES-NaP Diethylstilbestrol sodium phosphate (Honvol) |
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