Proriatic hair follicle cells |
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Authors: | M. C. Lenoir E. Vromans B. Shroot A. J. M. Vermorken |
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Affiliation: | (1) Department of Biochemistry, Centre International de Recherches Dermatologiques (C.I.R.D.), Valbonne, France;(2) Research Unit for Cellular Differentiation and Transformation, University of Nijmegen, Nijmegen, The Netherlands |
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Abstract: | Calmodulin levels were measured by radioimmuno-assay in freshly isolated and cultured psoriatic human scalp hair follicle cells. The mean value ± SEM for calmodulin was 1.97±0.15 ng calmodulin g-1 protein for 16 control subjects whereas calmodulin levels were significantly increased in psoriatic hair follicles, 2.93±0.26 ng calmodulin g-1 protein (uninvolved skin) for 18 patients and 3.09±0.21 ng calmodulin g-1 protein for involved skin derived hair follicles for 17 of these patients. In vitro, 3-week-old cultures of psoriatic keratinocytes contained less DNA and more calmodulin per DNA than their normal counterparts. When 6 week-old cultures of psoriatic and control hair follicle keratinocytes were compared, this difference disappeared. These results are related to the state of differentiation of these cultures. |
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