Dynamics of the NADP+ and NAD+ levels in the mycelium of P. nigricans Thom strains of varying productivity depending on the carbon source]

The levels of NADP+ and NAD+ in the mycelium of the highly productive strain 117 and low productive strain B of P. nigricans were studied by the 2nd, 5th, 9th and 13th days of development on the mineral medium in the presence of glucose, succinate or acetate. It was found that at the beginning of the growth the levels of NADP+ in both strains in the presence of the same carbon source were the same, just as the levels of NAD+ in the presence of glucose or succinate. The same strain had different levels of NADP+ in the presence of different carbon sources. The levels of NAD+ depended on both the carbon source and the strain. In the presence of glucose both nucleotides were accumulated by the end of the culture development and in greater amounts by strain 117. In the presence of succinate the maximum levels were observed at the beginning of the culture growth, while in the presence of accetate the maximum levels were recorded by the end of the culture development (strain 117) and by the 19th day (strain B). It is supposed that NAD+ is transformed into adenylates in the fungi.