Adsorption of bacteria to ion-exchange materials |
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| Authors: | E Litopoulou-Tzanetaki † A Bayliss ‡ RA Patchett ‡ RG Kroll ‡ |
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| Institution: | Department of Biology, University College London, Gower Street, London WC1E 6BT and Pharmaceuticals Division, ICI plc, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK |
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| Abstract: | The inhibitory effect of low levels of novobiocin on the growth of Escherichia coli was greatly enhanced by the presence of cationic compounds which alone produced no inhibitory effect. Diaminoacetone and spermidine were the most effective enhancers of the novobiocin effect, but N-(2-pyrimidinyl)-piperazine, methylglyoxyl-bis-(guanylhydrazone), agmatine, 3,3-diamino benzidine and 3-amino benzamidine also produced marked enhancement. There was slightly less effect of 4,5,6-triamino pyrimidine, pyridoxamine and 1,4-diamino piperazine whilst 1,3-diamino guanidine, moroxydine, tetra methyl p -phenylene diamine and 1,4-diamino-2-butanone were essentially ineffective as enhancers of novobiocin inhibition. It is suggested that the effective agents aid the penetration of novobiocin through the outer membrane. |
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