|
|||||
|
|
The discovery of a novel calcium channel blocker related to the structure of potassium channel opener cromakalim |
|
| Authors: | Karnail S Atwal John R McCullough Anders Hedberg Mary L Conder Syed Z Ahmed Gabriella Cucinotta Diane E Normandin |
| Institution: | Bristol-Myers Squibb Pharmaceutical Research Institute, P.O. Box 4000, Princeton, N.J. 08543-4000 USA |
| Abstract: | During our studies aimed at the identification of novel analogs of the potassium channel opener cromakalim (3), we serendipitously observed pyranoquinoline 4 to possess pure calcium channel blocking activity. The results of the studies conducted to confirm the calcium channel blocking mechanism of 4 are reported in this paper. |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ | |