Synthesis of cationic amphiphiles on the basis of deoxycholic acid

Cationic derivatives of deoxycholic acid with N,N-dimethylenediamine, epsilon-aminocaproic acid, and pyridine as polar heads were synthesized. The cationic groups were linked to 3alpha- and 12alpha-hydroxy groups of the steroid moiety through ester or urethane bonds. Liposomal formulations of the compounds synthesized may be used for gene delivery in cells. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no. 5; see also http: //www.maik.ru.