Synthesis and inhibitory activity against phosphatidylinositol 4-kinase of echiguanine analogs. |
| |
| Authors: | Y Saito K Kato K Umezawa |
| |
| Affiliation: | Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan. |
| |
| Abstract: | N-Substituted-2-amino-4(3H)-7H-oxopyrrolo[2,3-d]pyrimidine-5-carbo xamides and their ribofuranosyl and 2',3'-dideoxyribofuranosyl derivatives were prepared as membrane permeable echiguanine analogs and tested for their ability to inhibit phosphatidylinositol (PI) 4-kinase. The ethylamide 5 and the corresponding ribofuranosyl compound 11 inhibited PI 4-kinase with IC50 values of 0.02 and 2.4 micrograms/ml, respectively. |
| |
| Keywords: | |
|
|
