Systematic evaluation of genetic variation at the androgen receptor locus and risk of prostate cancer in a multiethnic cohort study |
| |
Authors: | Freedman Matthew L Pearce Celeste L Penney Kathryn L Hirschhorn Joel N Kolonel Laurence N Henderson Brian E Altshuler David |
| |
Institution: | Department of Genetics, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA. |
| |
Abstract: | Repeat length of the CAG microsatellite polymorphism in exon 1 of the androgen receptor (AR) gene has been associated with risk of prostate cancer in humans. This association has been the focus of >20 primary epidemiological publications and multiple review articles, but a consistent and reproducible association has yet to be confirmed. We systematically addressed possible causes of false-negative and false-positive association in >4,000 individuals from a multiethnic, prospective cohort study of prostate cancer, comprehensively studying genetic variation by microsatellite genotyping, direct resequencing of exons in advanced cancer cases, and haplotype analysis across the 180-kb AR genomic locus. These data failed to confirm that common genetic variation in the AR gene locus influences risk of prostate cancer. A systematic approach that assesses both coding and noncoding genetic variation in large and diverse patient samples can help clarify hypotheses about association between genetic variants and disease. |
| |
Keywords: | |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|