Effect of natural zeolites on renal functions and water-salt metabolism in rats

In vivo experiments on adult Wistar rats, it has been found that intake of natural zeolites resulted in temporary decrease of renal water, sodium and potassium excretion. At the same time, reabsorption of water and electrolytes increased. This effect was due to the stimulation of Na+, K(+)-ATPase activity in thick ascending limb of Henle loop and hormonal changes: increase of insulin, thyroxin and aldosterone concentration in plasma. The water and ion content in most of the tissues under study was higher in the experimental group than in control. It has been suggested that renal response in rats with zeolites intake was compensatory lower as a result of gastrointestinal losses of ions and ion accumulation in tissues.