Bile salts induce resistance to polymyxin in enterohemorrhagic Escherichia coli O157:H7 |
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| Authors: | Kus Julianne V Gebremedhin Ahferom Dang Vica Tran Seav-Ly Serbanescu Anca Barnett Foster Debora |
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| Affiliation: | Department of Chemistry and Biology, Ryerson University, 350 Victoria St., Toronto, ON M5B 2K3, Canada. |
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| Abstract: | Many enteric bacteria use bile as an environmental cue to signal resistance and virulence gene expression. Microarray analysis of enterohemorrhagic Escherichia coli O157:H7 (EHEC) treated with bile salts revealed upregulation of genes for an efflux system (acrAB), a two-component signal transduction system (basRS/pmrAB), and lipid A modification (arnBCADTEF and ugd). Bile salt treatment of EHEC produced a basS- and arnT-dependent resistance to polymyxin. |
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