Modular evolution of the purine biosynthetic pathway |
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Authors: | Kappock T J Ealick S E Stubbe J |
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Affiliation: | Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue 18-409, Cambridge, MA 02139, USA. kappock@wuchem.wustl.edu |
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Abstract: | Structural studies, sequence alignments, and biochemistry have provided new insights into the evolution of the purine biosynthetic pathway. The importance of chemistry, the binding of ribose 5-phosphate (common to all purine biosynthetic intermediates), and transient protein-protein interactions in channeling of chemically unstable intermediates have all been examined in the past few years. |
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