The design and synthesis of the high efficacy, non-peptide CCK1 receptor agonist PD170292 |
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Authors: | Bernad N Burgaud B G Horwell D C Lewthwaite R A Martinez J Pritchard M C |
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Institution: | CCIPE-Faculte de Pharmacie, Montpellier, France. |
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Abstract: | The design, synthesis and biological actions of a novel, non-peptide CCK1 receptor agonist (PD 170292) which exhibits a similar pharmacological profile to the CCK analogue JMV180 is reported. PD 170292 was designed based on a consideration of the structures of a peptide based CCK1 receptor selective agonist and a peptoid CCK2 receptor selective antagonist. |
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