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Pituitary metabolism of 5alpha-androstane-3beta-17beta-diol: intense and rapid conversion into 5alpha-androstane-3beta,6alpha,17beta-triol and 5alpha-androstane-3beta,7alpha, 17beta-triol. |
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| Authors: | J M Guiraud R Morfin B Ducouret S Samperez P Jouan |
| Abstract: | In the male rat pituitary, 5alpha-androstane-3beta, 17beta-diol (3beta-diol) is extensively metabolized into polar steroids. They were identified as 5alpha-androstane-3beta, 6alpha-17beta-triol (6alpha-triol) and 5alpha-androstane-3beta, 7alpha, 17beta-triol (7alpha-triol). 6-alpha-Triol represents 53% and 7alpha-Triol 28% of the total 3beta-diol metabolites. The remaining percentage is related to 6beta and 7beta isomers. The biological role of triols is still unknown. |
| Keywords: | Requests for reprints should be addressed to Prof. P. Jouan Laboratoire de Neurobiologie Moléculaire — Centre Régional de Recherche en Endocrinologie — Campus de Beaulieu — 35042 Rennes Cedex France. |
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