Thermodynamic interactions of a cis and trans benzanilide with Escherichia coli bacterial membranes |
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| Authors: | Sarah R Dennison Timothy J Snape David A Phoenix |
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| Institution: | School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston, PR1 2HE, UK. |
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| Abstract: | The activity of a membrane interactive cis and trans benzanilide against Escherichia coli membrane mimics was investigated using Langmuir monolayers. It was found that in the presence of E. coli lipid mix monolayers, cis-benzanilide induced maximal surface pressure changes of 1?mN?m(-1), whereas a reduced interaction was observed with trans-benzanilide. Compression isotherm analysis of these monolayers showed ?G (mix)?
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