Dipeptide Antagonists of Amino Acid-Induced and Synaptic Excitation in the Frog Spinal Cord |
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| Authors: | A. A. Francis A. W. Jones J. C. Watkinst |
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| Affiliation: | Department of Pharmacology, The Medical School, Bristol BS8 ITD, U.K.;Department of Physiology, The Medical School, Bristol BS8 ITD, U.K. |
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| Abstract: | Abstract: The dipeptide γ-d -glutamylglycine (γDGG) antagonizes amino acidinduced depolarization and synaptic excitation in the isolated hemisected spinal cord of the frog. In general, the effects of this compound resembled those of the structurally similar d -α-aminosuberate (DαAS) in being more effective against N-methyl-d -aspartate (NMDA)-induced responses than against responses induced by other excitatory amino acids. However γDGG appeared to be more effective than DαAS in depressing kainate-induced responses. Similar, though weaker, effects were produced by the L isomer of the dipeptide (αLGG), a natural brain constituent. |
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| Keywords: | γ-d-glutamylglycine Dipeptide antagonists |
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