| 赤芍中芍药苷提取工艺的优化 |
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| 引用本文： | 潘浪胜,吕秀阳,吴平东. 赤芍中芍药苷提取工艺的优化[J]. 天然产物研究与开发, 2006, 18(1): 105-107 |
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| 作者姓名： | 潘浪胜 吕秀阳 吴平东 |
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| 作者单位： | 1. 浙江大学材料与化工学院制药工程研究所,杭州,310027;湘潭大学化工学院,湘潭,411105
2. 浙江大学材料与化工学院制药工程研究所,杭州,310027 |
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| 基金项目： | 浙江省中医药科研基金研究计划项目(2005C188) |
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| 摘 要： | 本文提出一条从赤芍中提取芍药苷的工艺,包括醇水溶液回流提取、液液分配、硅胶柱层析等工序,并对各工序的操作条件进行了优化。采用优化后的提取工艺,可得到纯度大于97.0%的芍药苷产品,总回收率超过87.0%。本工艺具有产品纯度高、操作简单、成本低、回收率高、易于工业化等优点。
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| 关 键 词： | 赤芍 芍药苷 提取 工艺优化 |
| 文章编号： | 1001-6880（2006）01-0105-03 |
| 收稿时间： | 2005-05-30 |
| 修稿时间： | 2005-06-28 |
Process Optimization of Paeoniflorin Isolation from Paeonia veitchii Lynch |
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| PAN Lang-sheng,LV Xiu-yang,WU Ping-dong. Process Optimization of Paeoniflorin Isolation from Paeonia veitchii Lynch[J]. Natural Product Research and Development, 2006, 18(1): 105-107 |
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| Authors: | PAN Lang-sheng LV Xiu-yang WU Ping-dong |
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| Affiliation: | 1. Institute of Pharmaceutical Engineering, College of Materials Science and Chemical Engineering, Zhejiang University, Hangzhou 310027, China;2. College of Chemical Engineering, Xiangtan University, Xiangtan 411105, China |
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| Abstract: | Paeoniflorin is the major active compound in Paeonia veitchii Lynch.A process was established for isolating paeoniflorin from Paeonia veitchii Lynch,which includes extraction of Paeonia veitchii Lynch with ethanol-water solution,liquid-liquid extraction and silica gel column chromatography.The operating parameters in each step were optimized.With the process optimized,paeoniflorin with a purity over 97.0% can be prepared with the total recovery more than 87.0%.High purity products can be obtained with this process which is simple,low cost,high recovery and easy to scale up. |
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| Keywords: | Paeonia veitchii Lynch paeoniflorin isolation process optimization |
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