| D构象丝氨酸在中枢神经系统中的功能研究进展 |
| |
| 引用本文： | 阳洪波,袁建刚,彭小忠.D构象丝氨酸在中枢神经系统中的功能研究进展[J].生物化学与生物物理进展,2003,30(6):852-854. |
| |
| 作者姓名： | 阳洪波 袁建刚 彭小忠 |
| |
| 作者单位： | 中国医学科学院基础医学研究所,中国协和医科大学基础医学院,医学分子生物学国家重点实验室,北京,100005 |
| |
| 摘 要： | 哺乳动物中枢神经系统中D构象丝氨酸的区域性高浓度分布与N-甲基-D-天冬氨酸(NMDA)受体相一致.它主要由丝氨酸消旋酶将L丝氨酸直接消旋而来,也可能通过肠道菌群产生后吸收至体内,最终被D构象氨基酸氧化酶氧化.这种从胶质细胞而非神经元来源的“异常”构象氨基酸作为一种新型神经递质,不仅更新了传统“神经递质”的定义,而且为许多与NMDA受体过度兴奋或表达下调相关的神经系统疾病治疗提出了新的线索.
|
| 关 键 词： | D构象丝氨酸 丝氨酸消旋酶 NMDA受体 |
| 收稿时间： | 5/7/2003 12:00:00 AM |
| 修稿时间： | 2003年5月7日 |
Progress in The Function of D-serine in Mammalian Central Nervous System |
| |
| YANG Hong-Bo,YUAN Jian-Gang and PENG Xiao-Zhong.Progress in The Function of D-serine in Mammalian Central Nervous System[J].Progress In Biochemistry and Biophysics,2003,30(6):852-854. |
| |
| Authors: | YANG Hong-Bo YUAN Jian-Gang and PENG Xiao-Zhong |
| |
| Institution: | Institute of Basic Medical Science, Chinese Academy of Medical Sciences & Peking Union Medical College, National Laboratory of Medical Biology, Beijing 100005, China;Institute of Basic Medical Science, Chinese Academy of Medical Sciences & Peking Union Medical College, National Laboratory of Medical Biology, Beijing 100005, China;Institute of Basic Medical Science, Chinese Academy of Medical Sciences & Peking Union Medical College, National Laboratory of Medical Biology, Beijing 100005, China |
| |
| Abstract: | The regional high distribution of D-serine in mammalian central nervous system is consistent with that of N-methyl-D-aspartat e receptor. D-serine is synthesized by a glial serine racemase, a novel enzyme converting L- to D-serine in mammalian brain. D-amino acid oxi dase (DAO) is a flavoenzyme that catalyzes D-amino acids. D-serine as a glia- derived transmitter not only questions the basic ideas about "neurotransmitter" but also offers a novel way to treat some brain disorders as both over-stimulation and down regulation of NMDA receptors has been implicated in a large number of acute and chronic neurodiseases. |
| |
| Keywords: | D-serine serine racemase NMDA receptor |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《生物化学与生物物理进展》浏览原始摘要信息 |
| 点击此处可从《生物化学与生物物理进展》下载免费的PDF全文 |
|
