Ruthenium(III) dimethyl sulfoxide pyridinehydroxamic acid complexes as potential antimetastatic agents: synthesis,characterisation and in vitro pharmacological evaluation |
| |
| Authors: | Darren Griffith Sara Cecco Ennio Zangrando Alberta Bergamo Gianni Sava Celine J. Marmion |
| |
| Affiliation: | (1) Centre for Synthesis and Chemical Biology, Department of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland, 123 St. Stephen’s Green, Dublin 2, Ireland;(2) Fondazione Callerio, Via A. Fleming 22–31, 34127 Trieste, Italy;(3) Dipartimento di Scienze Chimiche, Universita di Trieste, Via L. Giorgieri 1, 34127 Trieste, Italy;(4) Dipartimento di Scienze Biomediche, Universita di Trieste, Via L. Giorgieri 7-9, 34127 Trieste, Italy |
| |
| Abstract: | Reaction of 3-pyridinehydroxamic acid and 4-pyridinehydroxamic acid (3-pyha and 4-pyha) with either [NBu4][RuCl4(dmso-S)2] or [(dmso)2H][RuCl4(dmso-S)2] (dmso is dimethyl sulfoxide) in acetone afforded three new ruthenium(III) dimethyl sulfoxide pyridinehydroxamic acid complexes: [NBu4][trans-RuCl4(dmso-S)(4-pyha)]·CH3COCH3 (1), [3-pyhaH][trans-RuCl4(dmso-S)(3-pyha)] (2) and [4-pyhaH][trans-RuCl4(dmso-S)(4-pyha)] (3). The solid-state structure of [NBu4][trans-RuCl4(dmso-S)(4-pyha)]·CH3COCH3 (1) was determined by X-ray crystallography. 2 and 3 were pharmacologically evaluated for their in vitro cytotoxicity, their ability to inhibit cell invasion and their gelatinase activity. 2 and 3 were devoid of cytotoxicity against the cell lines tested. 2 inhibited invasion of the highly invasive MDA-MB-231 cells to a much greater extent than 3. Contrary to expectations, neither 2 nor 3 had any inhibitory effect on matrix metalloproteinase (MMP) production and/or activity and in fact 3 was found to enhance the production and/or activity of both MMP-2 and MMP-9. |
| |
| Keywords: | Ruthenium Hydroxamic acid Cytotoxicity Metastasis Matrix metalloproteinase |
| 本文献已被 SpringerLink 等数据库收录！ |
|
