A dysregulated endocannabinoid-eicosanoid network supports pathogenesis in a mouse model of Alzheimer's disease期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

A dysregulated endocannabinoid-eicosanoid network supports pathogenesis in a mouse model of Alzheimer's disease

Authors:	Piro Justin R Benjamin Daniel I Duerr James M Pi YeQing Gonzales Cathleen Wood Kathleen M Schwartz Joel W Nomura Daniel K Samad Tarek A

Affiliation:	Neuroscience Research Unit, Pfizer Global Research and Development, Groton, CT 06340, USA.

Abstract:	Download : Download full-size image Highlights? Monoacylglycerol lipase (MAGL) is a major contributor to brain arachidonic acid pools ? MAGL mutation decreases neuroinflammation and amyloid β in Alzheimer's disease mouse ? MAGL blockade recapitulates brain prostaglandin and cytokine-lowering effects ? MAGL inhibitors may be a next-generation strategy for combating Alzheimer's disease

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