Pharmacology of airway afferent nerve activity |
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Authors: | Bradley J Undem Michael J Carr |
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Institution: | (1) Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, 21224 Baltimore, Maryland, USA |
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Abstract: | Afferent nerves in the airways serve to regulate breathing pattern, cough, and airway autonomic neural tone. Pharmacologic agents that influence afferent nerve activity can be subclassified into compounds that modulate activity by indirect means (e.g. bronchial smooth muscle spasmogens) and those that act directly on the nerves. Directly acting agents affect afferent nerve activity by interacting with various ion channels and receptors within the membrane of the afferent terminals. Whether by direct or indirect means, most compounds that enter the airspace will modify afferent nerve activity, and through this action alter airway physiology. |
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