秀丽隐杆线虫脂肪沉积研究进展

脂肪的过度沉积会引发多种疾病,如心脏病、高血压、高甘油三酯血症、Ⅱ型糖尿病等。小白鼠(Mus musculus)和猪(Sus domesticus)是常用的研究脂肪沉积的模式动物,近年来随着研究的深入,发现脂肪代谢调控网络错综复杂,调控因子相互作用。秀丽隐杆线虫(Caenorhabditis elegans)具有结构简单、身体透明、便于观察、繁殖周期短、易于人工培养等特征,因此使得秀丽隐杆线虫进行脂肪调控的研究成为了可能。本文通过总结国内外线虫脂肪沉积方面的研究,综述秀丽隐杆线虫研究脂肪沉积的进展。

Research Advance in the Regulation of Fat Deposition in Caenorhabditis elegans

Excessive deposition of fat will lead to lots of diseases, such as heart disease, hypertension, hypertriglyceridemia, type II diabetes, and other diseases. Mice(Mus musculus) and porcine(Sus domesticus) are commonly model to study lipid accumulation, but more and more research show that the regulation network of fat metabolism are very complex, and regulatory factors interact with each other, fat storage is a complex physiological process. Many key fat regulatory genes and fat metabolism pathways found in mammals are conserved in C. elegans. Therefore, C. elegans is a powerful genetic model for fat biology research. This article summarizes the fatty deposits of C. elegans domestic and international, and review the progress of C. elegans fat deposition.