Structure-activity relationships of carboxymethylpullulan-peptide-doxorubicin conjugates--systematic modification of peptide spacers |
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| Authors: | Nogusa H Yano T Kashima N Yamamoto K Okuno S Hamana H |
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| Institution: | Drug Delivery System Institute, Ltd., Chiba, Japan. |
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| Abstract: | A series of carboxymethylpullulan (CMPul)-doxorubicin (DXR) conjugates bound by peptide spacers of different compositions and lengths were prepared and evaluated for their in vivo antitumor effects. Systematic study of the peptide spacers indicated that CMPul-DXR conjugates bound via appropriate dipeptide spacers were more potent than DXR. |
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