Multi locus sequence typing of Chlamydiales: clonal groupings within the obligate intracellular bacteria Chlamydia trachomatis |
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| Authors: | Yvonne Pannekoek Giovanna Morelli Barica Kusecek Servaas A Morré Jacobus M Ossewaarde Ankie A Langerak Arie van der Ende |
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| Affiliation: | (1) Department of Medical Microbiology, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, The Netherlands;(2) Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany;(3) Department of Pathology, Laboratory of Immunogenetics, Section Immunogenetics of Infectious Diseases, & Department of Internal Medicine, Section Infectious Diseases, Free University Medical Center, Amsterdam, The Netherlands;(4) Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Centre and Laboratory of Medical Microbiology, Medisch Centrum Rijnmond-Zuid, Rotterdam, The Netherlands |
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| Abstract: | Background The obligate intracellular growing bacterium Chlamydia trachomatis causes diseases like trachoma, urogenital infection and lymphogranuloma venereum with severe morbidity. Several serovars and genotypes have been identified, but these could not be linked to clinical disease or outcome. The related Chlamydophila pneumoniae, of which no subtypes are recognized, causes respiratory infections worldwide. We developed a multi locus sequence typing (MLST) scheme to understand the population genetic structure and diversity of these species and to evaluate the association between genotype and disease. |
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