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| Advances in cellular technology in the hematology field: What have we learned so far? | |
| 作者姓名： | Gustavo Torres de Souza Claudinéia Pereira Maranduba Camila Maurmann de Souza Danielle Luciana Aurora Soares do Amaral Francisco Carlos da Guia Rafaella de Souza Salom?o Zanette Jo?o Vitor Paes Rettore Natana Chaves Rabelo Lucas Mendes Nascimento ícaro Fran?a Navarro Pinto Júlia Boechat Farani Abrah?o Elias Hallack Neto Fernando de Sá Silva Carlos Magno da Costa Maranduba Angelo Atalla |
| 作者单位： | Laboratory of Human Genetics and Cell Therapy, Biology Department, Biological Sciences Institute, Federal University of Juiz de Fora, Juiz de Fora 36036-900,Brazil;Haematology and Bone Marrow Transplantation Service, Medical Clinic Department, University Hospital, Federal University of Juiz de Fora, Juiz de Fora 36036-900, Brazil |
| 摘 要： | Despite the advances in the hematology field, blood transfusion-related iatrogenesis is still a major issue to be considered during such procedures due to blood antigenic incompatibility. This places pluripotent stem cells as a possible ally in the production of more suitable blood products. The present review article aims to provide a comprehensive summary of the state-of-theart concerning the differentiation of both embryonic stem cells and induced pluripotent stem cells to hematopoietic cell lines. Here, we review the most recently published protocols to achieve the production of blood cells for future application in hemotherapy, cancer therapy and basic research. |
| 关 键 词： | Hematopoietic stem cells Progenitor Induced pluripotent stem cells Reprogramming Embryonic stem cells |
| 收稿时间： | 2014-07-25 |
| 本文献已被 CNKI 等数据库收录！ | |