| DNA羟甲基化与表观遗传学调控 |
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| 引用本文： | 汤琳琳,麦一峰,段世伟. DNA羟甲基化与表观遗传学调控[J]. 中国生物化学与分子生物学报, 2014, 30(11): 1084-1091 |
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| 作者姓名： | 汤琳琳 麦一峰 段世伟 |
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| 作者单位： | 宁波大学医学院糖尿病研究中心,浙江省病理生理学技术研究重点实验室;宁波大学医学院附属医院 |
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| 基金项目： | 国家自然科学基金项目(No.31100919,81371469);浙江自然科学基金杰出青年项目(No.LR13H020003);宁波大学王宽诚幸福基金项目资助~~ |
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| 摘 要： | 表观遗传学中的DNA甲基化与疾病的发生发展密不可分. DNA甲基化中的5-甲基胞嘧啶易发生氧化形成5 羟甲基胞嘧啶.此过程又称为羟甲基化修饰，已成为表观遗传学研究的一种新热点.羟甲基化与10-11易位家族蛋白（ten-eleven translocation，TET）的作用密切相关，它参与了基因的表达调控以及DNA去甲基化过程. 最近的羟甲基化研究主要集中在癌症和精神性疾病.针对日趋增多的相关研究，本文对DNA羟甲基化进行了全景式综述.
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| 关 键 词： | 表观遗传学 羟甲基化 TET家族蛋白 组织特异性 |
| 收稿时间： | 2014-04-01 |
DNA Hydroxymethylation in Epigenetic Regulation |
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| TANG Lin-Lin;MAI Yi-Feng;DUAN Shi-Wei. DNA Hydroxymethylation in Epigenetic Regulation[J]. Chinese Journal of Biochemistry and Molecular Biology, 2014, 30(11): 1084-1091 |
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| Authors: | TANG Lin-Lin MAI Yi-Feng DUAN Shi-Wei |
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| Affiliation: | TANG Lin-Lin;MAI Yi-Feng;DUAN Shi-Wei;Zhejiang Key Laboratory of Pathophysiology,Diabetes Center,School of Medicine,Ningbo University;Affiliated Hospital,School of Medicine,Ningbo University; |
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| Abstract: | Epigenetic modification such as DNA methylation is closely related to the development of disease. The 5-methylcytosine tends to oxidize to 5 hydroxymethylcytosine. This process is defined as 5-hydroxymethylation that has become a new trend in the epigenetic study. Under the regulation of ten eleven translocation (TET) family proteins, hydroxymethylation plays an important role in the process of DNA demethylation and the regulation of gene expression. Recent hypoxymethylation studies are found in the research of cancers and mental diseases. Due to the increasing amount of studies on hypoxymethylation, the goal of our review is to present a landscape of the recent progress of hydroxymethylation. |
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| Keywords: | epigenetics hydroxymethylation ten-eleven translocation tissue specificity |
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