8-Oxo-2′-deoxyguanosine ameliorates features of metabolic syndrome in obese mice |
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Authors: | Seong-Hee Ko Jin-Ku Lee Hyun Joo Lee Sang-Kyu Ye Hyun-Sook Kim Myung-Hee Chung |
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Institution: | 1. Department of Food and Nutrition, College of Human Ecology, Sookmyung Women’s University, Seoul 140-742, South Korea;2. Department of Pharmacology and Biomedical Science, Seoul National University College of Medicine, Seoul 110-799, South Korea;3. Neuro-Immune Information Storage Network Research Center, Seoul National University College of Medicine, Seoul 110-799, South Korea;4. Department of Anatomy and Cell Biology, Sungkyunkwan University School of Medicine, Seoul 135-710, South Korea;5. Major in Medicine, Pusan University School of Medicine, Busan 602-739, South Korea;6. Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University School of Medicine, Seoul 135-710, South Korea |
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Abstract: | Metabolic syndrome describes a group of clinical features that together increase the incidence of coronary artery disease, stroke and type 2 diabetes. Insulin resistance is a major risk factor for developing metabolic syndrome. A chronic state of inflammation accompanies the accumulation of surplus lipids in adipose and liver tissue, frequently involved in insulin resistance. 8-Oxo-2′-deoxyguanosine (8-Oxo-dG) is a potent anti-inflammatory agent that inactivates both Rac1 and Rac2 which are critical to initiating the inflammatory responses in various cell types, including macrophages. In this study, we explored whether 8-Oxo-dG suppressed a series of systemic inflammatory cascades, resulting in the amelioration of typical features of metabolic syndrome in obese mice. The results demonstrate that 8-Oxo-dG effectively improved hyperglycemia, dyslipidemia and fatty liver changes in obese mice. The level of biochemical markers indicative of systemic inflammation were reduced in 8-Oxo-dG treated mice, whereas serum levels of adiponectin, a crucial factor associated with improved metabolic syndrome, were enhanced. Our results demonstrate that 8-Oxo-dG effectively disrupts the pathogenesis of insulin resistance and obesity-associated metabolic syndrome. |
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Keywords: | Metabolic syndrome Insulin resistance Inflammation 8-Oxo-deoxyguanosine |
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